What organizes the genome in the nucleus?

Spatial separation of active from inactive fractions of the genome in the cell nucleus is crucial for gene expression control. A new study uncovers leading mechanisms of such separation and turns our picture of the nucleus ...

Nuclear membrane Lem2 necessary for nuclear scaling

A study led by Hiroshima University finds that nuclear membrane protein Lem2 acts as a valve to control the size of the nucleus, keeping it in proportion to the size of the cell

Organizing a cell's genetic material from the sidelines

A tremendous amount of genetic material must be packed into the nucleus of every cell—a tiny compartment. One of the biggest challenges in biology is to understand how certain regions of this highly packaged DNA can be ...

Nanodiscs catch misfolding proteins red-handed

When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins ...

Chromosome mechanics guide nuclear assembly

Every one of our cells stores its genome within the nucleus – the quintessential subcellular structure that distinguishes eukaryotic cells from bacteria. When animal cells divide, they disassemble their nucleus, releasing ...

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