Molecules with potent bioactivity alone are not suitable for new medicines. They must behave well inside the body, being easily absorbed, yet metabolically stable, once circulating through the blood stream. Adding fluorine ...
Materials Science
Oct 5, 2012
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0
Taking an approach similar to that used for discovering new therapeutic drugs, chemists at the University of California, Davis, have found several compounds that can boost oil production by green microscopic algae, a potential ...
Biotechnology
Apr 8, 2013
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0
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...
Biochemistry
Feb 16, 2012
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0
A rare isotope in high demand for treating cancer is now more available to pharmaceutical companies developing and testing new drugs.
Materials Science
Mar 26, 2021
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22
Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...
Cell & Microbiology
Dec 8, 2022
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56
For several decades, snake venoms have been used in pharmacology to make new drugs. But a French team of pharmacologists, clinicians, systematists and conservation biologists, headed by Nicolas Vidal of the Laboratory “Systématique, ...
Plants & Animals
Mar 23, 2011
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0
Today, when new drugs are designed with the help of supercomputers, and electronic devices operate on a nanoscale, it is very important for scientists to understand how neighboring molecules behave towards each other. For ...
Materials Science
Mar 20, 2020
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68
A single mutation in the H5N1 avian influenza virus that affects the pH at which the hemagglutinin surface protein is activated simultaneously reduces its capacity to infect ducks and enhances its capacity to grow in mice ...
Cell & Microbiology
Feb 28, 2013
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0
A screening technique commonly used in drug discovery can yield important details about the actions of molecular 'glues' in protein interactions.
Biochemistry
Jun 8, 2023
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8
Every time a new cancer drug is announced, it represents hundreds of researchers spending years behind the scenes working to design and test a new molecule. The drug has to be not only effective, but also as safe as possible ...
Biochemistry
Apr 29, 2022
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