MicroRNAs are small molecules that regulate gene activity by binding to and destroying RNAs produced by the genes. More than 60% of all human genes are estimated to be regulated by microRNAs; therefore, it is not surprising ...
Cell & Microbiology
Sep 21, 2023
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A family of regulatory molecules, microRNAs, are key to the maintenance of fertility in both genders.
Cell & Microbiology
Sep 28, 2022
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8
In a study from the lab of Whitehead Institute Member David Bartel, researchers have identified genetic sequences that can lead to the degradation of cellular regulators called microRNAs in the fruit fly Drosophila melanogaster. ...
Cell & Microbiology
Sep 27, 2022
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23
Researchers are pursuing ever-more sophisticated treatments to tackle lung cancer. Traditional chemotherapy can have serious side-effects throughout the body, so many new treatments are highly targeted. These methods allow ...
Bio & Medicine
Jun 30, 2022
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63
The group led by Drs. Yoshinori Yoshida and Hirohide Saito succeeded in collecting and purifying large amounts of iPS cell-derived cardiomyocytes rapidly with the technology they newly developed by combining a cell sorting ...
Cell & Microbiology
Jun 14, 2022
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11
The brain is the organ that orchestrates all the diverse functions and complex decisions that take place in biological systems. Despite its critical nature, it is equally as fragile: the neurons that make up the brain do ...
Plants & Animals
Apr 27, 2022
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76
A team of student researchers from John Jay College of Criminal Justice has discovered human microRNA genes not shared with any other primate species and which may have played an important role in the unique evolution of ...
Evolution
Mar 8, 2022
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445
Known to be fine regulators of gene expression, microRNAs are small molecules that remain particularly stable in biofluids—blood, urine, etc. In humans, these molecules have revealed great potential as prognostic or diagnostic ...
Ecology
Dec 10, 2021
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5
After a gene is transcribed into RNA, modifications can occur to the subunits or "bases" that make up the RNA molecule, which can affect its structure and function. The study of these changes is known as "epitranscriptomics." ...
Biotechnology
Sep 29, 2021
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81
New research published in the Journal of Cellular and Molecular Medicine indicates that SARS-CoV-2, the virus that causes COVID-19, produces microRNAs that can have impacts on infected cells. MicroRNAs are genetic molecules ...
Molecular & Computational biology
Jun 23, 2021
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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression. They were first described in 1993 by Lee and colleagues in the Victor Ambros lab , yet the term microRNA was only introduced in 2001 in a set of three articles in Science.
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