Unlocking the biochemical treasure chest within microbes

Secondary metabolites—the compounds produced by microbes to mediate internal and external messaging, self-defense, and chemical warfare—are the basis for hundreds of invaluable agricultural, industrial, and medical products. ...

Researchers devise a new way to plot circadian clock

(Phys.org)—Everyone has an internal clock, that mysterious process which controls sleeping and hunger patterns, but now researchers are finding out that because the internal clock also controls metabolism, it would be helpful ...

New antifungal compound from ant farms

Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common ...

Identifying compound classes through machine learning

Everything that lives has metabolites, produces metabolites and consumes metabolites. These molecules arise as intermediate and end products from chemical processes in an organism's metabolism. Therefore, they not only have ...

Antibacterial prodrug by targeting intracellular metabolite

National University of Singapore researchers have developed an approach to selectively target pathogenic bacteria by harnessing an intracellular metabolite known as formate, abundant in these bacteria, as a new antimicrobial ...

Deep learning gives drug design a boost

When you take a medication, you want to know precisely what it does. Pharmaceutical companies go through extensive testing to ensure that you do.

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Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Examples of primary metabolites produced by industrial microbiology:

The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.

Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.

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