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A spring-loaded sensor for cholesterol in cells

Although too much cholesterol is bad for your health, some cholesterol is essential. Most of the cholesterol that the human body needs is manufactured in its own cells in a synthesis process consisting of more than 20 steps. ...

dateDec 07, 2017 in Biochemistry
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Nanodiscs catch misfolding proteins red-handed

When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers, including University of Michigan biophysicists, have obtained a structural snapshot of these proteins ...

dateDec 06, 2017 in Bio & Medicine
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How ribosomes shape the proteome

Cells are crowded with macromolecules, which limits the diffusion of proteins, especially in prokaryotic cells without active transport in the cytoplasm. While investigating the relationship between crowding, ionic strength ...

dateDec 06, 2017 in Cell & Microbiology
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