Malaria treatment resistance could be avoided by studying how resistance evolves during drug development, according to a new paper published in Cell Chemical Biology.
Biochemistry
May 9, 2019
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22
An experimental drug, called DSM265, cured seven volunteers of a Plasmodium falciparum infection, a malaria parasite that is a major cause of morbidity and mortality worldwide. The goal of this research is to find a cure ...
Cell & Microbiology
Mar 11, 2019
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4
Most malaria drugs are designed to reduce symptoms after infection. They work by blocking replication of the disease-causing parasites in human blood, but they don't prevent infection or transmission via mosquitoes. What's ...
Cell & Microbiology
Dec 6, 2018
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64
The antimalarial drug Mefloquine, branded as Lariam and used by many travellers to tropical countries, is a substance with two different forms of molecule. One form contains the active substance, but the other form causes ...
Materials Science
Dec 6, 2018
1
6
A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting. But if a drug-resistant strain does become ...
Cell & Microbiology
Aug 28, 2018
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40
For the first time, scientists have revealed the essential genes for the most deadly human malaria parasite, Plasmodium falciparum. Researchers from the Wellcome Sanger Institute and the University of South Florida (USF) ...
Cell & Microbiology
May 3, 2018
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20
Drug delivery systems (DDSs) control the dosage and timing of drugs. Numerous DDS studies have been conducted, but most have focused on treatments for cancer. New research from Kumamoto University uses a DDS to treat malaria.
Bio & Medicine
Mar 26, 2018
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22
Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets. The team are already working with pharmaceutical companies ...
Cell & Microbiology
Feb 20, 2018
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68
NUS scientists in collaboration with researchers from Norvatis have discovered two genetic markers in Plasmodium falciparum, the deadliest malaria parasite that can cause it to develop resistance against a new antimalarial ...
Cell & Microbiology
Jan 3, 2018
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76
Limiting a much-needed resource could pit pathogens against one another and prevent the emergence of drug resistance. New research demonstrates that harnessing competition among pathogens inside a patient could extend the ...
Cell & Microbiology
Dec 11, 2017
0
115
