In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called "lasso-grafting" to design therapeutics with enhanced longevity and brain penetration.
Biotechnology
Nov 8, 2022
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32
Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...
Biochemistry
Feb 22, 2021
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13
New computational strategies reported this week in Science might help realize the promise of peptide-based drugs. Peptides are similar to protein molecules, but differ in their smaller size, structure and functions.
Biochemistry
Dec 14, 2017
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143
Bacteria speak to one another using peptide signals in a soundless language known as quorum sensing. In a step towards translating bacterial communications, researchers at Princeton University have revealed the structure ...
Biochemistry
May 16, 2015
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39
There are currently only a few synthetic agents that bind to and block the widespread membrane transport proteins, ATP-binding cassette transporters (ABC). Scientists at Goethe University and the University of Tokyo identified ...
Molecular & Computational biology
May 17, 2021
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7
Hepatocyte Growth Factor (HGF) is a protein that acts as a cell growth factor. By binding to its receptor protein MET on the cell membrane, it exerts its physiological functions such as proliferation and migration of cells, ...
Biochemistry
May 29, 2019
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9
Thanks to our understanding of molecular biology, we have made tremendous progress in medicine, with scientists shedding light on the molecular mechanisms of several diseases. However, despite knowing how these diseases occur ...
Biochemistry
Sep 8, 2021
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40
