Solving streptide from structure to biosynthesis

Bacteria speak to one another using peptide signals in a soundless language known as quorum sensing. In a step towards translating bacterial communications, researchers at Princeton University have revealed the structure ...

Screening for macrocyclic peptides

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...

Biological lasso: Enhanced drug delivery to brain

In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called "lasso-grafting" to design therapeutics with enhanced longevity and brain penetration.

In slow motion against antibiotic resistance

There are currently only a few synthetic agents that bind to and block the widespread membrane transport proteins, ATP-binding cassette transporters (ABC). Scientists at Goethe University and the University of Tokyo identified ...