Biological lasso: Enhanced drug delivery to brain

In a study recently published in the journal Nature Biomedical Engineering, researchers from Kanazawa University use a method called "lasso-grafting" to design therapeutics with enhanced longevity and brain penetration.

Metallic complexes made from cyclic molecules

In polymetallic complexes, two or more metal atoms combine with organic molecules into larger, complicated molecular structures. Such complexes are used in the development of e.g. new catalysts, molecular magnets and sensors. ...

Pyrrole chemistry: Good things come in threes

A new approach leads to the long-awaited formation of rings made of three pyrroles, which could be used to produce compounds with a host of interesting properties, and explains why they have not been observed before.

In slow motion against antibiotic resistance

There are currently only a few synthetic agents that bind to and block the widespread membrane transport proteins, ATP-binding cassette transporters (ABC). Scientists at Goethe University and the University of Tokyo identified ...

Screening for macrocyclic peptides

Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...

Chemists create the brightest-ever fluorescent materials

By formulating positively charged fluorescent dyes into a new class of materials called small-molecule ionic isolation lattices (SMILES), a compound's brilliant glow can be seamlessly transferred to a solid, crystalline state, ...

Using molecules to draw on quantum materials

Over millennia, civilizations progressed through the Stone, Bronze, and Iron Ages. Now the time has come for quantum materials to change the way we live, thanks in part to research conducted at the Institut National de la ...

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