An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world's most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.
Molecular & Computational biology
13 hours ago
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31
Lysosomes are surrounded by a lipid bilayer that separates the acidic environment and the digestive enzymes of the organelle from the cytoplasm. Damage to this layer—lysosomal membrane permeabilization, or LMP for short—can ...
Cell & Microbiology
Apr 8, 2024
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17
Finding the best method to deliver chemotherapeutic drugs to tumor cells can be tricky. Ideally, the treatments target tumor cells while leaving healthy cells alone.
Bio & Medicine
Mar 12, 2024
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1
For centuries, coronaviruses have triggered health crises and economic challenges, with SARS-CoV-2, the coronavirus that spreads COVID-19, being a recent example. One small protein in SARS-CoV-2, the membrane protein, or ...
Cell & Microbiology
Feb 28, 2024
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79
Intrinsically disordered proteins (IDPs) are widely found in the proteomes of eukaryotes and play key roles in life processes such as transcription of genetic information and signaling. Apart from being usually highly repetitive, ...
Biochemistry
Jan 15, 2024
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18
Researchers at Kanazawa University report in Frontiers in Molecular Biosciences a computational method to predict the placement of proteins on AFM substrates based on electrostatic interactions
Molecular & Computational biology
Dec 13, 2023
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8
Lipids are the main constituents of our cell membranes, which are formed as lipid bilayers. The distribution of lipids is far from uniform; it is asymmetric, with different lipid compositions in the outside and inside layers. ...
Cell & Microbiology
Dec 5, 2023
0
10
Membrane proteins play a pivotal role in various cellular functions and are key targets for pharmaceutical interventions. In fact, approximately 60% of drugs currently available on the market target these specific proteins. ...
Molecular & Computational biology
Sep 7, 2023
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1
In living organisms, cells have a very high capacity to process and communicate information by moving molecules or ions through tiny channels that span the cell membrane. UC Santa Cruz Professor of Electrical and Computer ...
Bio & Medicine
Sep 6, 2023
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103
University of Oxford researchers have made a significant step towards realizing miniature bio-integrated devices, capable of directly stimulating cells. Their work has been published in the journal Nature.
Bio & Medicine
Aug 30, 2023
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45
