Ubiquitin ligases regulate many processes in living cells. Depending on how many ubiquitin molecules they attach to the target proteins and in which way, they control the protein's fate.
Cell & Microbiology
Feb 8, 2024
0
1
Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease. While some proteins must be synthesized at specific times, others require timely breakdown ...
Cell & Microbiology
Sep 21, 2023
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32
By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.
Biochemistry
Feb 15, 2023
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90
In a study published in The Plant Cell, researchers led by Li Yunhai at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences described a role for the endoplasmic reticulum (ER)–associated ...
Cell & Microbiology
Feb 10, 2023
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22
In plants, the phytohormone abscisic acid (ABA) plays a vital role in repressing seed germination and subsequent early seedling establishment, and ABA-INSENSITIVE 3 (ABI3) and ABI5 are two essential regulators of these developmental ...
Plants & Animals
Feb 7, 2023
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8
The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...
Biochemistry
Nov 3, 2022
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32
An important function of our cells' signaling pathways is to coordinate growth with environmental cues, such as the availability of nutrients in the cell's environment. Cell growth plays an important role in normal cell function—for ...
Cell & Microbiology
Jul 14, 2022
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441
Scientists have revealed two enzymes that regulate protein degradation of proteins in the cell membrane of plants, and established the roles they play in plant growth and development.
Plants & Animals
Jun 3, 2022
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21
As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond to the environment and ...
Plants & Animals
Apr 28, 2022
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94
Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells. Protein degraders, such as thalidomide ...
Molecular & Computational biology
Mar 8, 2022
0
19
