New molecule sets stage for nickel as a 'greener' photocatalyst, reveals key steps in reaction process
In recent years, the golden word in precious metals is palladium.
Materials Science
Apr 26, 2022
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149
News tagged with ligand
Related topics:
receptors
· cancer cells
Selective synthesis of meta isomers now possible
In a recent study published in Science, four RIKEN organic chemists have come up with a way to selectively synthesize isomers of an important group of aromatic compounds. This promises to make it possible to manufacture chemicals ...
Materials Science
Apr 22, 2022
0
39
DNA nanostructures for targeting cellular surface receptors
A broad subset of parameters, which include cell signaling modulation and receptor binding efficiency, can be explored using programmable DNA nanostructures. Glenn Cremers shows how these structures can uncover important ...
Cell & Microbiology
Apr 21, 2022
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8
Chemical reaction design goes virtual
Researchers at the Institute for Chemical Reaction Design and Discovery and Hokkaido University have developed a virtual ligand-assisted (VLA) screening method that could drastically reduce the amount of trial and error required ...
Materials Science
Mar 14, 2022
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22
Protein structure offers clues to drug-resistance mechanism
MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple ...
Biochemistry
Feb 18, 2022
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516
The first observation of oxygen-oxygen bond formation by a low-valent RuIII complex
Currently, the world's energy demand mainly depends on fossil fuels being a limited resource. The consumption of fossil fuels leads to emission of carbon dioxide (CO2) that is one of the major greenhouse gases contributing ...
Materials Science
Feb 11, 2022
0
121
Understanding how autoactivation triggers cell death
Apoptosis is a process that causes cell death. It can go awry in cancer cells, sustaining the disease. Scientists at St. Jude Children's Research Hospital have captured the structure of BAK, a protein that triggers apoptosis. ...
Cell & Microbiology
Jan 11, 2022
0
91
New route to the synthesis of P-chiral compounds
Chiral phosphines are one of the most commonly used ligands in assymetric metal catalysis for the synthesis of various useful drugs and pharmaceuticals. Have you ever wondered how to obtain them? Most of the so-called chiral ...
Materials Science
Jan 07, 2022
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55
Finding new potassium channels to selectively target pest insects
Ion channels in the nervous system are among the most important targets for insecticides. Understanding the structure of the channels is key for the identification of novel species-specific binding sites of agrochemicals. ...
Plants & Animals
Dec 14, 2021
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187
Using machine learning and computationally derived descriptors to find special classes of catalysts
A team of researchers at RWTH Aachen University and the University of Jyväskylä has developed a system based on machine learning and computationally derived descriptors that can be used to find special kinds of catalysts. ...
Ligand
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.
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