Through a Sensor, Holographically

( -- The power and resolution of lens-based optical microscopes have improved by orders of magnitude since their invention around 1595. Nevertheless, relying on a high-magnification lens for image clarity has ...

In a new microchip, cells separate by rolling away

Cell rolling is a common mechanism cells use to navigate through the body. During inflammation, for example, the endothelial cells that line blood vessels present certain molecules that attract white blood cells just enough ...

LEGO toy helps researchers learn what happens on nanoscale

Johns Hopkins engineers are using a popular children's toy to visualize the behavior of particles, cells and molecules in environments too small to see with the naked eye. These researchers are arranging little LEGO pieces ...

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A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single chip of only millimeters to a few square centimeters in size. LOCs deal with the handling of extremely small fluid volumes down to less than pico liters. Lab-on-a-chip devices are a subset of MEMS devices and often indicated by "Micro Total Analysis Systems" (µTAS) as well. Microfluidics is a broader term that describes also mechanical flow control devices like pumps and valves or sensors like flowmeters and viscometers. However, strictly regarded "Lab-on-a-Chip" indicates generally the scaling of single or multiple lab processes down to chip-format, whereas "µTAS" is dedicated to the integration of the total sequence of lab processes to perform chemical analysis. The term "Lab-on-a-Chip" was introduced later on when it turned out that µTAS technologies were more widely applicable than only for analysis purposes.

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