New method paves the way for new antibiotics

Norwegian University of Science and Technology (NTNU) researchers have developed a promising antibiotic candidate against MRSA. Behind the discovery lies a methodology that may be important in the fight against antimicrobial ...

The first potent COQ8 inhibitor targets ubiquinone biosynthesis

A new collaborative study from the University of Eastern Finland, Washington University in St. Louis, University of Wisconsin–Madison, University of North Carolina at Chapel Hill and the Promega Corporation discloses the ...

Resetting the biological clock by flipping a switch

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists ...

Using a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

Nanoshells could deliver more chemo with fewer side effects

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside ...

Probing the function of key proteins

"Kinase inhibitor" drugs, which target a class of enzymes that are crucial to keep cells running, make up one of the great success stories of modern medicine.

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