Light-induced changes in shape power a pump in a marine bacterium

RIKEN biochemists have discovered how a miniscule pump in a marine microbe shuttles negative ions into the cell by changing shape when activated by light. As well as providing insights into how these ion pumps work, the findings ...

Accurate drug dosages with proton traps

Researchers at Linköping University, Sweden, have developed a proton trap that makes organic electronic ion pumps more precise when delivering drugs. The new technique may reduce drug side effects, and in the long term, ...

Calcium bursts kill drug-resistant tumor cells

Multidrug resistance (MDR)—a process in which tumors become resistant to multiple medicines—is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that ...

Fat pumps generate electrical power

A previously unknown electrical current develops in the body's cells when the vital fat pump function of the flippases transfers ("flips") lipids from the outer to the inner layer of the body's cell membranes. This electrical ...

New insight into a central biological dogma on ion transport

New research results from Aarhus University and New York University show how active transport of potassium can be achieved by a membrane protein complex that has roots in both ion pump and ion channel super-families. The ...

Regulating plant physiology with organic electronics

A drug delivery ion pump constructed from organic electronic components also works in plants. Researchers from the Laboratory of Organic Electronics at Linköping University and from the Umeå Plant Science Centre have used ...

A calcium pump caught in the act

Researchers at Aarhus University have described one of the cell's key enzymes, the calcium pump, in its decisive moment—a so-called transition state. These findings provide a very detailed picture of how one of the most ...

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