Enhancing the efficacy of immunity-activating nucleic acid drugs

(Phys.org)—The Nanotechnology Innovation Station of the National Institute for Materials Science has succeeded in development of a technology which utilizes nanoparticles to enhance the action of immunity activating nucleic ...

The butterfly effect in nanotech medical diagnostics

Tiny metallic nanoparticles that shimmer in the light like the scales on a butterfly's wing are set to become the color-change components of a revolutionary new approach to point-of-care medical diagnostics, according to ...

Blocking protein may prevent blinding disease

Blocking a protein that battles infection may help thwart a common cause of vision loss in chronic diseases such as diabetes, Medical College of Georgia researchers say.

Interleukin 6

More reference expression data

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. In terms of host response to a foreign pathogen, IL-6 has been shown, in mice, to be required for resistance against the bacterium, Streptococcus pneumoniae. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery (Petersen, J Appl Physiol 2005). Additionally, osteoblasts secrete IL-6 to stimulate osteoblast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.

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