Related topics: influenza · virus · flu · vaccine · flu virus

New flu drug drives drug resistance in influenza viruses

On January 31, 2019, an 11-year old boy in Japan went to a medical clinic with a fever. The providers there diagnosed him with influenza, a strain called H3N2, and sent him home with a new medication called baloxavir.

How the influenza virus achieves efficient viral RNA replication

New insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication are provided by a study published October 3 in the open-access journal PLOS Pathogens by Nadia Naffakh of ...

Bat influenza viruses possess an unexpected genetic plasticity

Bat-borne influenza viruses enter host cells by utilizing surface exposed MHC-II molecules of various species, including humans. Now, an international research team from Germany (Medical Center—University of Freiburg and ...

Snapshots of the flu virus replication machine in action

Researchers from EMBL Grenoble have, for the first time, observed different functional states of the influenza virus polymerase as it is actively transcribing. These results, published in Nature Structural & Molecular Biology, ...

Virulence factor of the influenza A virus mapped in real-time

The influenza A viruses, which are responsible for deadly pandemics in the past, still remain a major global public health problem today. Molecules known as virulence factors are produced by bacteria, viruses, and fungi to ...

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Orthomyxoviridae

Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus

The Orthomyxoviridae (orthos, Greek for "straight"; myxa, Greek for "mucus") are a family of RNA viruses that includes five genera: Influenzavirus A, Influenzavirus B, Influenzavirus C, Isavirus and Thogotovirus. The first three genera contain viruses that cause influenza in vertebrates, including birds (see also avian influenza), humans, and other mammals. Isaviruses infect salmon; thogotoviruses infect vertebrates and invertebrates, such as mosquitoes and sea lice.

The three genera of Influenzavirus, which are identified by antigenic differences in their nucleoprotein and matrix protein infect vertebrates as follows:

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