New reaction facilitates drug discovery

Chemists at ETH Zurich have found a facile method that allows a commonly used building block to be directly converted into other types of important compounds. This expands the possibilities of chemical synthesis and facilitates ...

Enantioselective synthesis of indole derivatives

Indoles, and structures derived from them, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[ b ] indoles—frameworks made of three rings that are ...

Bioinspired acid-catalyzed C2 prenylation of indole derivatives

Biomimetic catalysis is an emerging concept that emulates key features of enzymatic process. Prenylation is a ubiquitous process found in almost all living organisms. Inspired by the enzymatic mechanism, researchers developed ...