Homologous recombination is an essential process of DNA repair to maintain genomic integrity of the organism. Now, researchers from Japan have identified mechanisms that choose between alternate pathways of DNA repair to ...
Evolution
Apr 30, 2020
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17
As eggs and sperm, or gametes, are formed during meiosis, chromosomes carrying the genetic material from each parent must find their partners, pair, and exchange parts of their DNA. This recombination is an important driving ...
Biotechnology
Mar 17, 2016
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18
In the world of biomolecules, none is more iconic, nor more versatile, than DNA. Nature uses the famous double helix to store the blueprints of all living forms, drawing on a four-letter alphabet of nucleotides.
Bio & Medicine
Oct 4, 2022
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48
Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact ...
Molecular & Computational biology
Jan 22, 2024
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36
(Phys.org)—A small team of researchers with the University of California has developed a way to use CRISPR/Cas9 to mimic mitotic recombination in yeast cells leading to a new way to map out genes and by doing so, determine ...
Researchers from several Russian institutes, including MIPT, have found out how prolonged exposure to ionizing radiation affects human stem cells. They discovered that it causes a cell cycle delay, which leads to faster repairs ...
Cell & Microbiology
Aug 25, 2017
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6
Systematically attenuating DNA targeting activity can achieve CRISPR-driven editing in bacteria, greatly boosting colony counts and even increasing the frequency of precise genome editing. This was shown in a study of the ...
Cell & Microbiology
Feb 9, 2023
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69
Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of ...
Biotechnology
Jun 4, 2015
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17
By studying the yeast used in beer- and bread-making, researchers at the University of Pittsburgh School of Medicine have uncovered the mechanism by which ancient proteins repair DNA damage and how their dysfunction could ...
Cell & Microbiology
Jul 28, 2015
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41
Pichia pastoris (syn. Komagataella phaffii), a model methylotrophic yeast, can easily achieve high density fermentation, and thus is considered as a promising chassis cell for efficient methanol biotransformation. However, ...
Molecular & Computational biology
Jul 9, 2021
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