Each year, about 1 million individuals worldwide become infected with HIV, the virus that causes AIDS. To replicate and spread the infection, the virus must smuggle its genetic material into the cell nucleus and integrate ...
Cell & Microbiology
Jan 25, 2024
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The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and other diseases, according ...
Biochemistry
Jun 30, 2022
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Researchers from Western University may have discovered a new meaning to the social media phrase, "going viral."
Evolution
May 5, 2022
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The introduction of foreign genes into cells has a range of benefits, such as compensating for dysfunctional genes in cells and producing large amounts of specific gene products that can be harvested and used clinically. ...
Cell & Microbiology
Oct 30, 2018
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Researchers at University of California, San Diego School of Medicine have discovered that HIV infection of human immune cells triggers a massive increase in methylation, a chemical modification, to both human and viral RNA, ...
Cell & Microbiology
Feb 22, 2016
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Scientists have sequenced the genome of the fungus Pneumocystis jirovecii, an advancement that could help identify new targets for drugs to treat and prevent Pneumocystis pneumonia, a common and often deadly infection in ...
Biotechnology
Dec 26, 2012
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Scientists at The Scripps Research Institute have used a powerful new chemical-screening method to find compounds that inhibit the activity of human immunodeficiency virus (HIV), the virus that causes AIDS. Unlike existing ...
Biochemistry
Jun 13, 2012
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(PhysOrg.com) -- An ancestor of the AIDS virus hijacked an entire gene, perhaps from some prehistoric cat it had infected, a gene that makes it much better able to infect humans, according to a study published online today ...
Cell & Microbiology
Dec 7, 2009
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A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. An international effort co-led by EPFL, Canada's ...
Biotechnology
Aug 2, 2023
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4
The HIV-1 capsid protein (CA) interacts with viral factors that support infection and host factors that restrict it. The host protein cyclophilin A (CypA) binds to CA and enhances the action of host restriction factors that ...
Cell & Microbiology
Sep 4, 2017
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