The importance of mixed motifs

Local modifications in histone proteins alter DNA packing density in the cell nucleus to regulate gene activity. They also form the basis of a code in which the significance of a given pattern or motif depends on its broader ...

Enhancer RNAs may open new avenues for gene therapy

A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy. According to the study researchers, altering the production and function of these molecules could ...

Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...