Related topics: stem cells · blood cells · leukemia · bone marrow

HSPC 'seeds' reveal VCAM-1+ macrophage role in homing process

Hematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that support life. HSPCs, like seeds, need a suitable microenvironment to maintain their function. A process called "homing" allows HSPCs to ...

SATB1 vital for maintenance of hematopoietic stem cells

Blood plays the important role of transporting oxygen and hormones necessary for the human body. Blood contains blood cells, such as erythrocytes, neutrophils, and lymphocytes, which are generated from hematopoietic stem ...

The prevalence of twin births in pure Spanish horses (PREs)

It is known that chromosomal anomalies are one of the principle genetic causes of infertility in horses. However, a great proportion of these cases still go undiagnosed, probably due to the fact that their symptomatology ...

Mechanism vital to keeping blood stem cells functional uncovered

Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function – and defective regulation of protein production is common in certain types of aggressive human blood cancers. ...

Which type of cell to become: Decision through indecision

From the moment of fertilization, building a human body involves a series of choices where cells generated by cell division must elect which of the myriad types of cell they will become. How does this decision occur? New ...

Deep learning predicts hematopoietic stem cell development

Autonomous driving, automatic speech recognition, and the game Go: Deep Learning is generating more and more public awareness. Scientists at the Helmholtz Zentrum München and their partners at ETH Zurich and the Technical ...

How RNA could keep us young

With over 75 million baby boomers in the U.S. alone, age-related diseases are a major concern in the health care system. The connection between aging and cancer has become a pillar in medicine: we know that as we age, our ...

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.

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