If a delivery person leaves a package on your front step without pinging you, you likely won't know it's there. A hungry cell awaiting refuel is in a similar position. It has to be alerted to the presence of nutrients outside ...
Cell & Microbiology
Nov 6, 2023
0
155
Antitumor agents must kill off cancer cells while protecting healthy tissue and create no toxic side-effects. A novel approach based on "self-immolative" polyferrocenes—copolymers that split apart into their components ...
Biochemistry
Jun 21, 2023
0
43
A recent study published in Sensors and Actuators: B. Chemical highlights the development of highly active oxidase mimics using MnOx nanobelts (NBs) generated through laser irradiation in liquid (LIL) techniques by researchers ...
Bio & Medicine
Apr 25, 2023
0
4
Chemists from the University of North Carolina at Greensboro released a study in the journal Antioxidants revealing a new basis for the link between dietary selenium and COVID-19 severity. Building on a previous study that ...
Biochemistry
Mar 3, 2023
1
207
New research provides fresh insight into how an important class of molecules are created and moved in human cells.
Biochemistry
Sep 2, 2022
0
695
Many of the processes that keep us alive also put us at risk. The energy-producing chemical reactions in our cells, for example, also produce free radicals—unstable molecules that steal electrons from other molecules. When ...
Cell & Microbiology
Nov 4, 2021
0
555
Epoxy resin is a type of thermoset resin commonly used in glue, paint and composite materials. NIMS and ISMA have developed a new thermoset plastic recycling system capable of easily decomposing epoxy resins in an aqueous ...
Polymers
Aug 26, 2021
0
109
The conventional view is that high temperatures cause microorganisms to replicate slowly or die. In this current textbook view, microorganisms combat heat-induced damage on their own. Reporting in Nature Microbiology, Delft ...
Cell & Microbiology
Apr 21, 2020
0
64
Charge transfer and separation is a fundamental process in the energy conversion that powers life on Earth. Besides deployment in solar cells and photocatalysts, this process is found in photosynthesis, as it enables energy ...
Materials Science
Apr 30, 2019
0
6
Cyanide exposure can happen occupationally or in low levels from inhaling cigarette smoke—or from being poisoned by someone out to get you. The effects are fast and can be deadly. But because cyanide is metabolized quickly, ...
Materials Science
Feb 27, 2019
0
7
Glutathione (GSH) is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.
Thiol groups are reducing agents, existing at a concentration of approximately 5 mM in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form glutathione disulfide (GSSG), also called L(-)-Glutathione.
Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor. The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular toxicity.
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