Scientists unveil the functional landscape of essential genes

A team of scientists at Whitehead Institute and the Broad Institute of MIT and Harvard have systematically evaluated the functions of more than 5,000 essential human genes using a novel, pooled, imaged-based screening method. ...

Molecular mechanism involved in the cholesterol cell transport

A team of the University of Barcelona (UB) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) identified a mechanism involved in the movement of cholesterol inside the cells. The study, published in the Journal ...

Revealing the molecular mechanism of nucleolar RNA

A research group led by Prof. Guang Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. Feng Xuezhu from the First Affiliated Hospital of USTC, ...

A groundbreaking genetic screening tool for human organoids

Many of the fundamental principles in biology and essentially all pathways regulating development were identified in so-called genetics screens. Originally pioneered in the fruit fly Drosophila and the nematode C. elegans, ...

Factors that ensure cellular protein production

Defects in tRNA biogenesis influence gene expression and are associated with many types of human diseases, such as cancer and neurological diseases. In his thesis, Fu Xu contributes to new knowledge about the factors that ...

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