Related topics: genome · genes · protein · genetic variation · dna

New AI tool makes speedy gene-editing possible

An artificial intelligence program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

Study reveals new insights on the mechanism of melanin formation

The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults. Melanin—a natural pigment produced by specialized skin cells ...

AI tailors artificial DNA for future drug development

With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells' protein production. The technology can contribute to the development and ...

How bacteriophage resistance shapes Salmonella populations

Researchers from the Quadram Institute and the University of East Anglia have uncovered how resistance has helped drive the emergence of dominant strains of Salmonella. In addition to antimicrobial resistance, resistance ...

Genetic 'hitchhikers' can be directed using CRISPR

In a new study, North Carolina State University researchers characterize a range of molecular tools to rewrite—not just edit—large chunks of an organism's DNA, based on CRISPR-Cas systems associated with selfish genetic ...

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Genetic code

The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. The code defines a mapping between tri-nucleotide sequences, called codons, and amino acids. A triplet codon in a nucleic acid sequence usually specifies a single amino acid (though in some cases the same codon triplet in different locations can code unambiguously for two different amino acids, the correct choice at each location being determined by context). Because the vast majority of genes are encoded with exactly the same code (see the RNA codon table), this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact there are many variant codes. Thus the canonical genetic code is not universal. For example, in humans, protein synthesis in mitochondria relies on a genetic code that varies from the canonical code.

It is important to know that not all genetic information is stored using the genetic code. All organisms' DNA contain regulatory sequences, intergenic segments, and chromosomal structural areas that can contribute greatly to phenotype but operate using distinct sets of rules that may or may not be as straightforward as the codon-to-amino acid paradigm that usually underlies the genetic code (see epigenetics).

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