'Unassuming' enzyme opens way for new medical treatments

It sounds like a plot for a Cold War thriller—training a gene to infiltrate a cell and reside there, unnoticed, until an external self-destruct signal induces it to destroy its new home.

Landing therapeutic genes safely in the human genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)." These are ...

Bacterial viruses: Faithful allies against antibiotic resistance

It is a fact that bacteria are increasingly developing antibiotic resistance. Information campaigns have raised awareness among the general public that the main cause of antibiotic resistance is the high 'selection pressure' ...

Treatment with gene therapy of a new rat model of Morquio A

A research team from the Universitat Autònoma de Barcelona (UAB) has generated the first rat model recapitulating all disabling alterations experienced by patients with Mucopolysaccharidosis type IVA, also known as Morquio ...

Making sense of antisense gene silencing

Gene silencing therapies are used to interfere with, or 'silence', the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies ...

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