In situ sequencing of the fully structured genome

There is a sense in which the information encoded in a gene sequence can be represented by two bits per base pair location. The reality, however, is that this is far from a complete description. Although many academically ...

CRISPR technology shown to dial down gene activity in bacteria

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9—as a genetic dimmer switch for CRISPR-Cas9 ...

Antibiotic resistance from random DNA sequences

An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance can arise from completely ...