Evolutionary assimilation of foreign DNA in a new host

All life is subject to evolution in the form of mutations that change the DNA sequence of an organism's offspring, after which natural selection allows the 'fittest' mutants to survive and pass on their genes to future generations. ...

New understanding of CRISPR-Cas9 tool could improve gene editing

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic ...

Bread mould avoids infection by mutating its own DNA

Whilst most organisms try to stop their DNA from mutating, scientists from the UK and China have discovered that a common fungus found on bread actively mutates its own DNA as a way of fighting virus-like infections.

Gene found that causes eyes to wither in cavefish

Mexican cavefish spend their entire lives in the dark. With no need for vision, many of them lost functional eyes. In more than 30 varieties of Mexican cavefish, the eyes stop developing as embryos grow into larvae. Although ...

Taming CRISPR's collateral damage

CRISPR-Cas9 can alter genes at pre-defined sites in specific ways, but it does not always act as planned. An LMU team has now developed a simple method to detect unintended "on-target" events, and shown that they often occur ...

page 9 from 32