Related topics: receptors · membrane proteins

New possible target for treating major common diseases

There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...

Cryo-EM reveals structure and mechanism of the 5-HT3 receptor

In November 2017, a Titan Krios cryo-electron microscope (cryo-EM) was inaugurated at the ESRF, the European Synchrotron, France. Data collected on this cryo-EM features in a Nature publication describing the activation cycle ...

A step ahead in pharmaceutical research

Hormones and other neurotransmitters, but also drugs, act upon receptors. "Their active substances bind to the receptors and modify the three-dimensional receptor arrangement regulating the downstream signal pathways," says ...

Scientists alter membrane proteins to make them easier to study

About 30 percent of the proteins encoded by the human genome are membrane proteins—proteins that span the cell membrane so they can facilitate communication between cells and their environment. These molecules are critical ...

Cryo-EM reveals interaction between major drug targets

For the first time, scientists have visualized the interaction between two critical components of the body's vast cellular communication network, a discovery that could lead to more effective medications with fewer side effects ...

Tracing water channels in cell surface receptors

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal recognized at the extracellular ...

page 1 from 2