Nanopore reveals shape-shifting enzyme linked to catalysis

University of Groningen scientists have observed the characteristics of a single enzyme inside a nanopore. They learned that the enzyme can exist in four different folded states, or conformers, that play an active role in ...

Composing new proteins with artificial intelligence

Proteins are the building blocks of life, and consequently, scientists have long studied how they can improve proteins and design completely new proteins that perform new functions and processes.

Simple single-step N-terminal modification of proteins

Proteins are widely used in medicine, biology and chemistry. Enhancing their inherent properties by adding functional molecules to their structures is a common and important step in many fields. For example, adding fluorescent ...

Surfing on quantum waves: Protein folding revisited

Two physicists from the University of Luxembourg have now unambiguously shown that quantum-mechanical wavelike interactions are indeed crucial even at the scale of natural biological processes.

Mitochondrial unfolded protein response signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. LMU biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

New protein-sensing mechanism discovered

In a stunning discovery, molecular biologists from the University of Konstanz and ETH Zurich have been able to demonstrate that the nascent polypeptide-associated complex (NAC) senses newly synthesized proteins upon birth ...

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