Mitochondrial unfolded protein response signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. LMU biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

New protein-sensing mechanism discovered

In a stunning discovery, molecular biologists from the University of Konstanz and ETH Zurich have been able to demonstrate that the nascent polypeptide-associated complex (NAC) senses newly synthesized proteins upon birth ...

How do cellular machines unfold misfolded proteins?

Protein chains typically fold to function. Folding is a complex process and if done correctly leads to a unique functional fold topology for a given protein chain. Other topologies are also possible but are often non-functional ...

Self-folding metamaterial

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam ...

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