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A way to minimize unexpected base edits to cellular RNA

A team of researchers with the Broad Institute of Harvard and MIT has found evidence showing that using base editors can lead to unexpected RNA cellular edits. In their paper published in the journal Science Advances, the ...

CRISPR base editors can induce wide-ranging off-target RNA edits

A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, ...

Tricks to reduce DNA base editor's mistakes

Researchers at the Center for Genome Engineering, within the Institute for Basic Science (IBS, South Korea) have identified the mistake rate of DNA editing tools known as adenine base editors, which are based on CRISPR. Assessing ...

Chemists warm up to preprint servers

Preprint servers—online sites that post scientific manuscripts for free, prior to peer review—are well-established in fields such as physics and biology. More recently, two chemistry preprint servers, ChemRxiv and ChemRN, ...

Bringing medieval literature into the digital age

William Langland likely wouldn't know what to make of the latest way people are reading his poetry. In part, that's because Langland died in 1386. But it's also because his most famous work, Piers Plowman, is the subject ...

Lab safety, 10 years later

On December 29, 2008, staff scientist Sheri Sangji was working on a chemical synthesis in a lab at the University of California, Los Angeles, when one of the reagents ignited. Sangji's clothes caught fire, causing injuries ...

Modifying a virtual environment in just a few clicks

Creating and modifying a virtual reality environment just got a lot easier thanks to software being released today by Imverse, an EPFL spin-off. The secret behind Imverse's program, which works much like a photo editor, is ...

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