Learning from nature's bounty: New libraries for drug discovery

Natural products, or their close derivatives, make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. The size and complexity of macrocycles has made it difficult ...

When changing one atom makes molecules better

The development and improvement of pharmaceuticals plays the central role in the ongoing battle against human disease. Organic synthesis is the field that enables these developments as it offers the toolbox to diversify chemical ...

Supercrystals with new architecture can enhance drug synthesis

Scientists from ITMO University and Trinity College have designed an optically active nanosized supercrystal whose novel architecture can separate organic molecules, thus considerably facilitating the technology of drug synthesis. ...

Lab simplifies total synthesis of anti-cancer agent

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells.

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