Biting into a chili pepper causes a burning spiciness that is irresistible to some, but intolerable to others. Scientists exploring the chili pepper's effect are using their findings to develop a new drug candidate for many ...
Biochemistry
Aug 20, 2014
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Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. ...
Biochemistry
Apr 21, 2014
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It's difficult and time-consuming to produce accurate computer models of molecules, primarily because traditional modeling methods are limited in their ability to handle alternative molecular shapes and, consequently, are ...
Cell & Microbiology
Sep 26, 2013
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New research shows a physical characterisation of the interface of the body's proteins with water. Identifying the locations where it is easiest to remove water from the interface of target proteins could constitute a novel ...
Materials Science
Jul 30, 2013
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Ben-Gurion University of the Negev (BGU) researchers, in collaboration with Teva Pharmaceutical Industries Ltd., have developed a promising drug candidate to treat psoriasis. The finding was reported in a new paper published ...
Biochemistry
Mar 20, 2013
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A powerful computational technique used by the pharmaceutical industry to expedite new drug development has just received a performance boost. Chandra Verma and his co-workers at the A*STAR Bioinformatics Institute in Singapore ...
Biochemistry
Jan 30, 2013
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The Wyss Institute for Biologically Inspired Engineering at Harvard University today announced that it has entered into a Cooperative Agreement worth up to $37 million with the Defense Advanced Research Projects Agency (DARPA) ...
Engineering
Aug 11, 2012
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(Phys.org) -- Many drug candidates fail because of low solubility or poor pharmacokinetic behavior. Ron Raines and colleagues at the University of Wisconsin–Madison (USA) have devised a new prodrug strategy to overcome ...
Biochemistry
Aug 6, 2012
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(Phys.org) -- New drug candidates require testing in animal models prior to approval for clinical use. A recently developed antagonist based on a bicyclic peptide inhibited the human serine protease plasma kallikrein potently ...
Biochemistry
Apr 13, 2012
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The search for new drug candidates for cancer treatment is laborious and time-consuming. Only a fraction of the promising chemical compounds identified completes the transition to the market. Herbert Waldmann and his team ...
Biochemistry
Feb 28, 2012
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