Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the highly regulated enzymatic ...
Cell & Microbiology
Jul 10, 2023
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92
Precise control of gene expression—ensuring that cells make the correct components in the right amount and at the right time—is vital for all organisms to function properly. Cells must regulate how genes encoded in the ...
Cell & Microbiology
Feb 10, 2023
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70
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), ...
Biotechnology
Aug 25, 2022
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83
The enzyme that makes RNA from a DNA template is altered to slow the production of ribosomal RNA (rRNA), the most abundant type of RNA within cells, when resources are scarce and the bacteria Escherichia coli needs to slow ...
Biotechnology
Jan 22, 2021
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21
The discovery of a huge number of long non-protein coding RNAs, aka lncRNAs, in the mammalian genome was a major surprise of the recent large-scale genomics projects. An international team including a bioinformatician from ...
Biotechnology
May 15, 2020
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252
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.
Molecular & Computational biology
Apr 5, 2019
0
121
CRISPR has been hailed as one of the most promising gene editing technologies and promises to revolutionize precision medicine and eradicate genetic diseases. However, the technique is not perfect and needs improvements. ...
Biotechnology
Apr 9, 2018
0
32
In a future of personalized medicine, doctors may quickly glean the changes in the DNA sequences of patients that predispose them to specific diseases or determine the most appropriate therapeutic approach simply by analyzing ...
Biotechnology
Oct 11, 2016
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1
The activation of genes is a complicated biochemical endeavor akin to cooking a meal, and a new Yale study details just how precisely choreographed those steps need to be.
Cell & Microbiology
Mar 25, 2016
0
10
All the tissues in the human body are made from proteins, and for every protein, there's a stretch of DNA in the human genome that "codes" for it, or describes the sequence of amino acids that will produce it.
Biotechnology
Jan 28, 2016
0
81
