Pros and cons of genetic scissors

Crispr technology has greatly facilitated gene editing. Associate Professor Thorsten Müller from Ruhr-Universität Bochum and Dr. Hassan Bukhari from Harvard Medical School discuss its pros and cons in a review article in ...

How new loops in DNA packaging help us make diverse antibodies

Diversity is good, especially when it comes to antibodies. It's long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies ...

Organizing a cell's genetic material from the sidelines

A tremendous amount of genetic material must be packed into the nucleus of every cell—a tiny compartment. One of the biggest challenges in biology is to understand how certain regions of this highly packaged DNA can be ...

Knotty problems in DNA

If you've ever tried to untangle a pair of earbuds, you'll understand how loops and cords can get twisted up. DNA can get tangled in the same way, and in some cases, has to be cut and reconnected to resolve the knots. Now ...

New technique enables safer gene-editing therapy using CRISPR

Scientists from The University of Texas at Austin took an important step toward safer gene-editing cures for life-threatening disorders, from cancer to HIV to Huntington's disease, by developing a technique that can spot ...

What's a knot—and what's not—in genomic mapping

While DNA sequencing provides precise, nucleotide-by-nucleotide genomic information, genome mapping provides a bigger-picture perspective of sequenced DNA that can provide valuable structural information. Like mapping roads ...

Researchers discover unique DNA editing function

A species of unicellular ciliate has found a special trick to make use of the cellular machinery in seemingly impossible ways. Researchers at the University of Bern have for the first time described a mechanism in detail ...

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