How molecular scissors cut in the right place

A research group at Uppsala University has found out how CRISPR-Cas9—also known as 'molecular scissors'—can search the genome for a specific DNA sequence. Cas9 already has many applications in biotechnology and is also ...

Scientists map key DNA protein complex at near-atomic resolution

Chalking up another success for a new imaging technology that has energized the field of structural biology, researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) obtained the highest ...

Deciphering potent DNA toxin's secrets

One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.

Video imaging of single molecule DNA replication

Almost all life on Earth is based on DNA being copied, or replicated. Now for the first time scientists have been able to watch the replication of a single DNA molecule, with some surprising findings. For one thing, there's ...

A new approach to amplifying DNA

Analyzing DNA is useful for a number of vital applications. This includes diagnosis and monitoring of diseases, identification of criminals, and studying the function of a targeted segment of DNA. However, methods used for ...

Electrons use DNA like a wire for signaling DNA replication

In the early 1990s, Jacqueline Barton, the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry at Caltech, discovered an unexpected property of DNA—that it can act like an electrical wire to transfer electrons quickly ...

How breaks in DNA are repaired

A team of researchers from the biology department at TU Darmstadt has discovered that the processes for repairing DNA damage are far more complex than previously assumed. The ends of breaks in the double helix are not just ...

Hijacking the double helix for replication

For years, scientists have puzzled over what prompts the intertwined double-helix DNA to open its two strands and then start replication. Knowing this could be the key to understanding how organisms - from healthy cells to ...

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