Transcription is a cellular process by which genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information ...
Biochemistry
Aug 21, 2012
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Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.
Cell & Microbiology
Jun 19, 2009
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When cells experiencing DNA damage fail to repair themselves, they send a signal to their neighbors letting them know they're in trouble. The discovery, which shows that a process dubbed the DDR (DNA Damage Response) also ...
Cell & Microbiology
Jul 13, 2009
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In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by ...
Cell & Microbiology
Jan 30, 2014
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Chromosomal instability is a phenomenon characterized by rapid changes in the number and structure of chromosomes during cell division. It is very common in solid tumors and it is linked to the aggressive spread of cancer, ...
Cell & Microbiology
Sep 26, 2023
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12
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The finding suggests that the delay itself ...
Biochemistry
Jan 28, 2015
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52
Each year at least 2 million Americans are infected with bacteria that cannot be treated with antibiotics, and at least 23,000 of these people die, according to the Centers for Disease Control.
Environment
Apr 8, 2019
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37
When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis.
Biochemistry
Apr 10, 2009
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Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular "alarm bell" to alert the cell to start the repair process, but until recently little was known about how the cell detects and ...
Cell & Microbiology
Aug 13, 2009
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Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with Fanconi anemia and how otherwise healthy people are susceptible to cancer from environmentally ...
Cell & Microbiology
Mar 25, 2010
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