When a building is damaged, a general contractor often oversees various subcontractors—framers, electricians, plumbers and drywall hangers—to ensure repairs are done in the correct order and on time.
Biotechnology
Dec 13, 2018
0
73
DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...
Molecular & Computational biology
Oct 29, 2018
0
48
Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites ...
Cell & Microbiology
Oct 16, 2017
0
68
Scientists at the Francis Crick Institute have made a surprising discovery about the Vaccinia virus, a large DNA virus belonging to the pox family that was used as the vaccine to eradicate smallpox.
Cell & Microbiology
May 3, 2017
0
197
Earlier work from the laboratory of Susan Gasser had noted changes in the physical behavior of chromatin when it incurred DNA damage: loci bearing double-strand breaks showed enhanced movement, becoming highly dynamic. Furthermore, ...
Cell & Microbiology
Jan 10, 2017
0
12
New research has revealed the function of a widely shared enzyme component, the Zf-GRF domain, as a critical molecular tool necessary for manipulating DNA during repair processes.
Cell & Microbiology
Jan 7, 2017
0
26
An international team of scientists has discovered how compounds block flap endonuclease 1 (FEN1) - a crucial enzyme class in the DNA damage response and potential target for cancer treatment.
Cell & Microbiology
Aug 17, 2016
0
47
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed.
Cell & Microbiology
Jul 3, 2015
72
5312
The DNA molecule is chemically unstable, giving rise to DNA lesions of various kinds. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. The DNA damage response ...
Cell & Microbiology
Mar 31, 2015
1
1773
Scientists at The Scripps Research Institute (TSRI) have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress.
Biotechnology
Oct 2, 2014
0
0
