Earlier work from the laboratory of Susan Gasser had noted changes in the physical behavior of chromatin when it incurred DNA damage: loci bearing double-strand breaks showed enhanced movement, becoming highly dynamic. Furthermore, ...
Cell & Microbiology
Jan 10, 2017
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12
New research has revealed the function of a widely shared enzyme component, the Zf-GRF domain, as a critical molecular tool necessary for manipulating DNA during repair processes.
Cell & Microbiology
Jan 7, 2017
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26
An international team of scientists has discovered how compounds block flap endonuclease 1 (FEN1) - a crucial enzyme class in the DNA damage response and potential target for cancer treatment.
Cell & Microbiology
Aug 17, 2016
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47
In bacteria, toxin-antitoxin systems consist of a set of two closely linked genes. Situated on the same chromosome, they encode both a protein 'poison' and a counteracting 'antidote'. Under normal conditions, the antitoxin ...
Cell & Microbiology
Feb 22, 2016
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6
The IMCB was established in 1987 at the National University of Singapore before becoming an autonomous research institute of A*STAR and moving to Biopolis in 2004. The IMCB strives to maintain the scientific excellence of ...
Cell & Microbiology
Jan 6, 2016
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4
The DNA molecule is chemically unstable giving rise to DNA lesions of different nature. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed.
Cell & Microbiology
Jul 3, 2015
72
5312
How does our body keep its DNA intact? Researchers at Erasmus MC have just found a new piece of this puzzle. They discovered a novel alarm that cells use to signal DNA damage. "We already knew that DNA damage triggers an ...
Cell & Microbiology
Jun 25, 2015
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14
The DNA molecule is chemically unstable, giving rise to DNA lesions of various kinds. That is why DNA damage detection, signaling and repair, collectively known as the DNA damage response, are needed. The DNA damage response ...
Cell & Microbiology
Mar 31, 2015
1
1773
Our genomes encounter DNA damaging events continuously. As damage accumulates, our cells react and stop the cell division process, giving repair mechanisms time to act. To achieve this, two master protein kinases called ATR ...
Cell & Microbiology
Dec 19, 2014
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0
Scientists at The Scripps Research Institute (TSRI) have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress.
Biotechnology
Oct 2, 2014
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