A bacterial toxin that acts as a mediator rather than a killer

Traditionally, bacterial toxins have been seen as killers of target cells. But is there more than meets the eye? Umeå University Professor Teresa Frisan and her team have discovered that toxin-host interactions are more ...

Researchers uncover mechanism behind DNA damage control

DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...

To repair DNA damage, plants need good contractors

When a building is damaged, a general contractor often oversees various subcontractors—framers, electricians, plumbers and drywall hangers—to ensure repairs are done in the correct order and on time.

Biologists discover source for boosting tumor cell drug sensitivity

DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...

Plants fix DNA differently from animals

In mammalian cells, the transcription factor p53 most responsible for healthy growth of the organism. The equivalent in plants is Suppressor Of Gamma Response 1 (SOG1), a factor that does not share a common evolutionary ancestor ...

Structural insights into processes at DNA damage sites

Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites ...

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