New nanoparticle drug combination for atherosclerosis developed

Physicochemical cargo-switching nanoparticles (CSNP) designed by KAIST can help significantly reduce cholesterol and macrophage foam cells in arteries, which are the two main triggers for atherosclerotic plaque and inflammation.

Researchers find a way to synthesize small cyclodextrins

A team of researchers at Kwansei Gakuin University in Japan has found a way to synthesize small cyclodextrins (types of cyclic oligosaccharides) for the first time. In their paper published in the journal Science, the group ...

Separation a sweet success

Sugars can make excellent gatekeepers for separating mixtures of molecules. A KAUST team has discovered a way to make a selectively porous membrane by linking large numbers of sugar structures, known as cyclodextrins, to ...

Edible carbon dioxide sponge

(PhysOrg.com) -- A year ago Northwestern University chemists published their recipe for a new class of nanostructures made of sugar, salt and alcohol. Now, the same team has discovered the edible compounds can efficiently ...

Self-Assembling Gold Nanoparticles Use Light to Kill Tumor Cells

(PhysOrg.com) -- A variety of studies by numerous investigators are demonstrating that gold nanoparticles have real promise as anticancer agents. When irradiated with light, gold nanoparticles become hot quickly, hot enough ...

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Cyclodextrin

Cyclodextrins (sometimes called cycloamyloses) are a family of compounds made up of sugar molecules bound together in a ring (cyclic oligosaccharides).

Cyclodextrins are produced from starch by means of enzymatic conversion. They are used in food, pharmaceutical, and chemical industries, as well as agriculture and environmental engineering. Hydroxypropyl Beta Cyclodextrin (HPßCD) is the chief active compound found in Procter and Gamble's deodorizing product "Febreze" under the brand name "Clenzaire".

Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). The 5-membered macrocycle is not natural. Recently, the largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units, while as a poorly characterized mixture, even at least 150-membered cyclic oligosaccharides are also known. Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape. thus denoting:

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