Cryo-electron microscopy is now the most popular method for determining protein structures, which helps researchers develop drugs for different kinds of ailments. Over the last several decades, it has replaced X-ray crystallography ...
Biochemistry
Jul 29, 2019
0
40
Using cutting-edge electron microscopy, researchers from Aarhus University have determined the first structures of a lipid-flippase. The discoveries provide a better understanding of the basics of how cells work and stay ...
Cell & Microbiology
Jun 27, 2019
0
0
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational Biology
May 30, 2019
0
82
Protein nanomachines made of multiple protein molecules are highly dynamic during their actions on their functional targets, sometime called substrates. Dynamics of these large protein nanomachines of more than megadalton ...
Biochemistry
Feb 26, 2019
0
7
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy ...
Biochemistry
Feb 08, 2019
0
160
People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn't been entirely clear how we do ...
Biochemistry
Feb 07, 2019
0
75
Studies of human monoclonal antibodies isolated from survivors of coronavirus-induced severe acute respiratory syndrome (SARS) or Middle-East respiratory syndrome (MERS) are unveiling surprising immune defense tactics against ...
Biochemistry
Jan 31, 2019
0
50
DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn't all that useful if it remains unopened and unread. In order to transcribe DNA, the enzyme RNA polymerase, or RNAP, must ...
Molecular & Computational Biology
Jan 10, 2019
0
1
Proteins do most of the real work in cells and are modified in accordance with functional requirements. An LMU team has now shown how proteins are chemically altered on the ribosome, even before they fold into the active ...
Cell & Microbiology
Dec 20, 2018
0
15
Portland State University researchers have made a significant breakthrough by developing the 3-D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door ...
Biochemistry
Dec 12, 2018
0
87
