Discovery offers starting point for better gene-editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases. However, there is a last-mile problem—these tools need to be effectively ...

New 3D structure could lead to future drugs against cancer

A team of scientists has created a three-dimensional map showing how a small molecule with anticancer properties—called spliceostatin—can promote the killing of cancer cells. This fundamental discovery could ultimately ...

New technology solves mystery of respiration in Tetrahymena

Tetrahymena, a tiny single celled-organism, turns out to be hiding a surprising secret: it's doing respiration—using oxygen to generate cellular energy—differently from other organisms such as plants, animals or yeasts. ...

Wrangling an octopus-like viral replication machine

Endemic in Western African countries, Lassa virus is transmitted to humans through food or household items that are contaminated with the urine or feces of Mastomys rats. Even though many people who become infected with Lassa ...

Microscopy opens doors for studying neurological diseases

The intricate functions of cellular processes have mystified scientists for decades. But with the help of tools like cryogenic electron microscopy (Cryo-EM), researchers at Penn State College of Medicine are starting to see ...

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