G protein-coupled receptors (GPCRs) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases. Upon binding to extracellular agonists, GPCRs stimulate various ...
Cell & Microbiology
Mar 19, 2020
0
126
The Epstein-Barr virus is one of the most widespread human viruses. Part of the herpesvirus family, it causes glandular fever (infectious mononucleosis), cancer and autoimmune diseases. At present, there is no treatment for ...
Cell & Microbiology
Feb 14, 2020
0
5
A team of molecular and structural biologists from Nanyang Technological University, Singapore (NTU Singapore), has found a potential new route to disabling respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) ...
Cell & Microbiology
Dec 09, 2019
0
48
When cells in our bodies need to move—to attack an infection or heal a wound, for example—cellular proteins send and receive a cascade of signals that directs the cells to the right place at the right time. It's a process ...
Biochemistry
Oct 16, 2019
0
93
Cells consist of a multitude of molecular structures, some of them exhibiting a staggering complexity. Ribosomes, the protein factories of the cell, belong to the biggest and most sophisticated complexes and are made up of ...
Cell & Microbiology
Sep 19, 2019
0
64
Cryo-electron microscopy is now the most popular method for determining protein structures, which helps researchers develop drugs for different kinds of ailments. Over the last several decades, it has replaced X-ray crystallography ...
Biochemistry
Jul 29, 2019
0
40
Using cutting-edge electron microscopy, researchers from Aarhus University have determined the first structures of a lipid-flippase. The discoveries provide a better understanding of the basics of how cells work and stay ...
Cell & Microbiology
Jun 27, 2019
0
0
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
0
82
Protein nanomachines made of multiple protein molecules are highly dynamic during their actions on their functional targets, sometime called substrates. Dynamics of these large protein nanomachines of more than megadalton ...
Biochemistry
Feb 26, 2019
0
7
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy ...
Biochemistry
Feb 08, 2019
0
160
