An unexpected mode of action for an antibody

Studies of human monoclonal antibodies isolated from survivors of coronavirus-induced severe acute respiratory syndrome (SARS) or Middle-East respiratory syndrome (MERS) are unveiling surprising immune defense tactics against ...

Enzyme structure reveals how DNA is opened up for transcription

DNA is a molecular manual that contains instructions for building life. And, like any manual, DNA isn't all that useful if it remains unopened and unread. In order to transcribe DNA, the enzyme RNA polymerase, or RNAP, must ...

A molecular hammock for cotranslational modification

Proteins do most of the real work in cells and are modified in accordance with functional requirements. An LMU team has now shown how proteins are chemically altered on the ribosome, even before they fold into the active ...

Biologists show inner workings of cellular 'undertaker'

One of a cell's most important responsibilities is to break down and recycle proteins that are no longer needed or endanger the cell. This task is carried out by a cellular nanomachine called the proteasome.

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