Related topics: brain · drug · neurons

Adapting Ritalin to tackle cocaine abuse

Cocaine use continues to be a public health problem, yet despite concerted efforts, no drugs have been approved to resolve cocaine addiction. Research suggests that the attention-deficit/hyperactivity disorder drug methylphenidate ...

Cocaine synthesized in a tobacco plant

A team of researchers at the Chinese Academy of Sciences, working with a colleague from Syngenta Jealott's Hill International Research Centre in the U.K., has developed a way to synthesize cocaine using a tobacco plant. The ...

How plants make cocaine

Cocaine is one of the most commonly used (and abused) drugs, but we have almost no modern information on how plants produce this complex alkaloid. Researchers from the Max Planck Institute for Chemical Ecology in Jena, Germany, ...

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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