Image: Cold plasma tested on ISS

Low-temperature plasma – electrically charged gas – that was originally tested aboard the International Space Station is now being harnessed to kill drug-resistant bacteria and viruses that can cause infections in hospital.

Underwater forests a treasure trove of new drugs

Defensive compounds produced by microbes are a major source of antibiotics and other important medicines. But with resistant bugs appearing faster than potential allies, researchers are taking their search for drug candidates ...

Turning stem cells into bone with nanoclay-reinforced hydrogel

Assistant Professor Alireza Dolatshahi-Pirouz and colleagues have developed a hydrogel that combines synthetic materials with living cells, and can turn stem cells into bone without adding external growth or differentiation ...

How accurate are dog-activity trackers?

There are countless gadgets available these days for people to track everything from our heart rate to our stress levels. So perhaps it's no surprise that there also are quite a few products that now claim to similarly monitor ...

Revealing the path of a metallodrug in a breast cancer cell

Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic ...

New AI can detect urinary tract infections

New AI developed at the University of Surrey could identify and help reduce one of the top causes of hospitalisation for people living with dementia: urinary tract infections (UTI).

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Clinical trial

In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.

Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.

Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization

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