Researchers uncover mechanism behind DNA damage control

DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...

DNA origami full of potent anticancer agents

One of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance. Chinese scientists have now developed a nanoplatform that selectively ...

Nanoshells could deliver more chemo with fewer side effects

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside ...

A multidrug efflux pump in motion

Researchers at Vanderbilt University Medical Center have mapped the conformational changes that occur in a protein "notorious" for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching ...

The problem and potential solution of combining drugs

Drugs are combined in endless ways—chemotherapy and anti-nausea pills; Advil and multivitamins; blood pressure medication and anti-depressants. Include treatments such as the herbs and acupuncture of traditional Chinese ...

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