New class of compounds offers great potential for research and drug development
Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.
Scientists from The Scripps Research Institute have identified a class of compounds that could be a boon to basic research and drug discovery.
Biochemistry
May 15, 2011
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(PhysOrg.com) -- Flasks, beakers and hot plates may soon be a thing of the past in chemistry labs. Instead of handling a few experiments on a bench top, scientists may simply pop a microchip into a computer and instantly ...
Analytical Chemistry
Aug 3, 2009
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Polypharmacology—the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical ...
Biochemistry
Jun 2, 2021
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A research team led by Dr. Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU), in collaboration with scientists from Tsinghua University in China, the Rockefeller University, and the University ...
Biochemistry
Nov 7, 2018
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Researchers at the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme ...
Biochemistry
Sep 6, 2018
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A subset of protein complexes whose role has long been thought to consist only of chemically degrading and discarding of proteins no longer needed by cells appears to also play a role in sending messages from one nerve cell ...
Cell & Microbiology
Mar 13, 2017
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To find out what activates SIRT6, the researchers alternately applied chemical inhibitors to human skin cells to determine which proteins were essential in getting the gene to repair the broken DNA strands. They discovered ...
Cell & Microbiology
Sep 9, 2016
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(Phys.org)—Scientists at The Scripps Research Institute (TSRI) have discovered the first selective inhibitors of an important set of enzymes. The new inhibitors, and chemical probes based on them, now can be used to study ...
Biochemistry
Oct 31, 2012
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Scientists at Yale University have developed the first practical method to create a compound called huperzine A in the lab. The compound, which occurs naturally in a species of moss found in China, is an enzyme inhibitor ...
Biochemistry
Aug 25, 2011
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A research team led by U of T Mississauga scientists has developed a new way to split up a dangerous pair of cancer proteins, a finding that could ultimately lead to chemotherapy that is more effective and has fewer side ...
Biochemistry
Aug 20, 2009
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