Mitochondrial unfolded protein response signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. LMU biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

A new signaling pathway for mTor-dependent cell growth

The activation of mTor complex 1 in the cell is central to many vital processes in the body such as cell growth and metabolism. Overactivity of this signaling pathway can result in diseases such as in diabetic insulin resistance ...

Using a promiscuous inhibitor to uncover cancer drug targets

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.

Researchers uncover mechanism behind DNA damage control

DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. ...

How bird feather patterns form

Feathers evolved in dinosaurs and are a key characteristic of birds today. They are arranged in a precise hexagonal pattern in a bird's skin, but it has been unclear how this happens. According to a new study published February ...

How plants learned to save water

Tiny pores on the leaves of plants, called stomata, have a huge influence on the state of our planet. Through the stomata, plants absorb carbon dioxide, which is incorporated into carbohydrates, and release oxygen. But they ...

When a fish becomes fluid

Zebrafish aren't just surrounded by liquid, but turn liquid—in part—during their development. As the zebrafish embryo develops from a ball of cells to a fully-formed fish, a region of the embryo switches its phase from ...

A game of pool in the live cell

Cells need to react to environmental changes and maintain a balanced system of signaling cascades within the cell. Proteins outside of the cell, on the cellular surface, inside the cellular membrane, and within the cell orchestrate ...

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