Old skin cells reprogrammed to regain youthful function

Research from the Babraham Institute has developed a method to "time jump" human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute's ...

Stem cell secrets allow researchers to revamp reprogramming

Researchers from the Babraham Institute's Epigenetics research program have been able to learn more about naïve stem cell reprogramming following a genome wide functional screen. Their research, published today in Science ...

Protein domain structures affect the quality of stem cells

The original iPS cells were reprogrammed by transducing four genes: OCT3/4, SOX2, KLF4, and c-MYC. Later experiments would show that c-MYC can be replaced with MYCL. Both are MYC proteins and thus oncogenes, but animal experiments ...

Sperm discovery reveals clue to genetic 'immortality'

New insights into an elusive process that protects developing sperm cells from damage in growing embryos, sheds light on how genetic information passes down, uninterrupted, through generations.

Researchers create functional mini-liver by 3-D bioprinting

Using human blood cells, Brazilian researchers have obtained hepatic organoids ("mini-livers") that perform all of the liver's typical functions, such as producing vital proteins, storing vitamins and secreting bile, among ...

Silencing retroviruses to awaken cell potential

Embryonic stem cells have the potential to differentiate into any type of cell in the human body. Once differentiated though, the newly minted somatic cells live out the rest of their days as that specific cell type and never ...

Not all stem cells are created equal, study reveals

Researchers from the University of Toronto's Institute for Biomaterials and Biomedical Engineering (IBBME) and the Donnelly Centre have discovered a population of cells – dubbed to be "elite" – that play a key role in ...

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