Unveiling the mechanism protecting replicated DNA from degradation

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein ...

To proliferate or not to proliferate? A cellular spring replies

The epithelium, a tissue made up of closely juxtaposed cells, forms the glands and covers the outer surface of the human body as well as its internal cavities, such as the lungs or intestines. There are different types of ...

SIRT6 ability to suppress cancer cell growth is explained

For several years, scientists have known that SIRT6 – one of seven sirtuins, a family of mammalian proteins with important biological functions, including promoting longer, healthier life – is a tumor suppressor. It has ...

A moving story of FHL2 and forces

Researchers from the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have revealed the molecular events leading to the regulation of cell growth and proliferation in response to stiffness of the ...

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